Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/13558
Título : Polyphenols and IUGR pregnancies : intrauterine growth restriction and hydroxytyrosol affect the development and neurotransmitter profile of the hippocampus in a pig model
Autor : Yeste Vizcaino, Natalia.
Gómez Trias, Néstor.
Vázquez Gómez, Marta.
García Contreras, Consolación.
Pumarola i Batlle, Martí.
González de Bulnes López, Antonio.
Bassols Teixidó, Anna.
Materias: Hippocampus (Brain) - Effects of chemicals on.Neurotransmisores.Neurotransmitters.Alimentos - Aditivos.Swine - Neurology.Hidroxitirosol - Efectos fisiológicos en los animales.Hydroxytyrosol - Physiological effect.Hipocampo (Cerebro) - Efectos de los productos químicos.Cerdos - Neurología.Food additives.
Fecha de publicación : 22-sep-2021
Editorial : MDPI
Citación : Yeste, N., Gómez, N., Vázquez-Gómez, M., García-Contreras, C., Pumarola, M., González-Bulnes, A. & Bassols, A. (2021). Polyphenols and IUGR pregnancies: intrauterine growth restriction and Hydroxytyrosol affect the development and neurotransmitter profile of the hippocampus in a pig model. Antioxidants, vol. 10, i. 10 (22 sep.), art. 1505. DOI: https://doi.org/10.3390/antiox10101505
Resumen : Intrauterine growth restriction (IUGR) refers to poor growth of a fetus during pregnancy due to deficient maternal nutrition or oxygen supply. Supplementation of a mother’s diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of IUGR. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of the total gestational period), and fetuses were sampled at day 100 of gestation. Fetuses were classified as normal body weight (NBW) or low body weight (LBW) as a consequence of IUGR, constituting four groups: NBW-Control, NBW-HTX, LBW-Control, and LBW-HTX. The brain was removed, and the hippocampus, amygdala, and prefrontal cortex were rapidly dissected. Neuronal markers were studied by immunohistochemistry, and a decrease in the number of mature neurons in the hippocampal Cornu Ammonis subfield 1 (CA1) and the Dentate Gyrus (DG) regions was observed in LBW fetuses together with a higher number of immature neurons and other alterations in neuronal morphology. Furthermore, IUGR conditions altered the neurotransmitter (NT) profile, since an increase in the serotonin (5-HT) pathway was observed in LBW fetuses. Supplementation with HTX was able to reverse the morphological and neurochemical changes, leading both characteristics to values similar to those of NBW fetuses.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2076-3921/10/10/1505
Este artículo pertenece al número especial "Natural or Synthetic Antioxidants for Neurodegenerative Diseases and Brain Health".
Idioma: en
es
URI : http://hdl.handle.net/10637/13558
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2076-3921 (Electrónico)
Aparece en las colecciones: Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Polyphenols_Yeste_ANTIOXIDANTS_2021.pdf5,12 MBAdobe PDFVisualizar/Abrir



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.