Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/13693
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.contributor.otherProducción Científica UCH 2021-
dc.creatorLópez Pedrajas, Rosa María.-
dc.creatorAlmansa Frías, María Inmaculada.-
dc.creatorSánchez Villarejo, María Victoria.-
dc.creatorMuriach Saurí, Borja.-
dc.creatorBarcia González, Jorge Miguel.-
dc.creatorRomero Gómez, Francisco Javier.-
dc.creatorMuriach Saurí, María.-
dc.date2021-
dc.date.accessioned2022-05-03T04:00:37Z-
dc.date.available2022-05-03T04:00:37Z-
dc.date.issued2021-10-08-
dc.identifier.citationLópez-Pedrajas, R., Almansa, I., Sánchez-Villarejo, M.V., Muriach, B., Barcia, J.M., Romero, F.J. & Muriach, M. (2021). Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats. Scientific Reports, vol. 11, art. 20033 (08 oct.). DOI: https://doi.org/10.1038/s41598-021-99448-w-
dc.identifier.issn2045-2322 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/13693-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-021-99448-w.pdf-
dc.description.abstractCocaine can induce severe neurobehavioral changes, among others, the ones involved in learning and memory processes. It is known that during drug consumption, cocaine-associated memory and learning processes take place. However, much less is known about the effects of this drug upon the mechanisms involved in forgetting.The present report focuses on the mechanisms by which cocaine affects memory consolidation of experiences acquired prior to drug administration. We also study the involvement of hippocampus in these processes, with special interest on the role of Nuclear factor kappa B (NF-κB), N-methyl-D-aspartate glutamate receptor 2B (GluN2B), and their relationship with other proteins, such as cyclic AMP response element binding protein (CREB). For this purpose, we developed a rat experimental model of chronic cocaine administration in which spatial memory and the expression or activity of several proteins in the hippocampus were assessed after 36 days of drug administration. We report an impairment in memory acquisition of experiences gathered prior to cocaine administration, associated to an increase in GluN2B expression in the hippocampus. We also demonstrate a decrease in NF-κB activity, as well as in the expression of the active form of CREB, confirming the role of these transcription factors in the cocaine-induced memory impairment.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.language.isoes-
dc.publisherNature Research-
dc.relationEste artículo de investigación ha sido financiado parcialmente por la Generalitat Valenciana (PROMETEO/2016/094 y GV/2019/125) y por la Universitat Jaume I (UJI-B2019-38) de España.-
dc.relationUCH. Financiación Autonómica-
dc.relation.ispartofScientific Reports, vol. 11 (08 oct. 2021)-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectSistema nervioso - Enfermedades.-
dc.subjectNeurosciences.-
dc.subjectNeurociencias.-
dc.subjectCocaine consumption - Physiological effect.-
dc.subjectMemory disorders.-
dc.subjectCocaína - Consumo - Efectos fisiológicos.-
dc.subjectNervous system - Diseases.-
dc.subjectMemoria - Trastornos.-
dc.titleRole of hippocampal NF-kappa B and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.1038/s41598-021-99448-w-
dc.relation.projectIDPROMETEO/2016/094-
dc.relation.projectIDGV/2019/125-
dc.relation.projectIDUJI-B2019-38-
Aparece en las colecciones: Dpto. Ciencias Biomédicas

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Role_Lopez_SR_2021.pdf1,4 MBAdobe PDFVisualizar/Abrir



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.